DNA haplotype screening in breeding dogs
It is common knowledge that champions in the judging ring do not necessarily produce champion offspring. But even a deliberate choice of males for the breeding bitch at home can lead to health problems in the offspring.
But why is this so?
If you pay attention to a low inbreeding coefficient (less than 5%) and a high ancestral loss coefficient (more than 85% in 5 generations, it is optimal to consider 12 generations) for your puppies, you are already on the right track. Since pedigrees in the past were often incomplete and one or the other does not match the truth, the pedigree-based inbreeding coefficient is incorrect.
It is also important to note that the entire litter cannot have the same inbreeding coefficient!
Example: You take 10 dice and roll them across the table. I add up the numbers I have now gotten from each cube. The numbers are not the same the next time you roll the dice across the table! If I assume there are 10 puppies in my litter and I roll 10 times I always have different numbers. It is the same with genes!
They are reshuffled for each puppy. Half from the father and half from the mother and many hundreds of thousands of times when it is formed in the womb. This mixing creates the very personal inbreeding coefficient of the dog.
But even genetically perfect dogs with good genetic diversity can cause surprises with a "wrong" mate.
When both parents' genes just don't match.
If the parents both have the same "bad genes" on the same chromosome, this can reveal health problems in the offspring of that mating.
The so-called DNA haplotype screening involves checking the dog's complete DNA to later determine the best mates using the Mate Select Tool.
It is clear in litters with HD-free parents that did not produce any HD A-A offspring, for example, that this is no guarantee. Further problems can result from inappropriate mate selection....
* Autoimmune diseases
* Immune system how well it works in diseases
* Fertility/sperm quality
* Metabolic diseases
How do I know who matches?
If both parents have undergone haplotype screening, all matching partners are listed in the Boerboel International Database in an easy-to-understand overview.
Correctly interpreting the value of genetic diversity (genetic inbreeding coefficient).
A dog with a low inbreeding value, taking 13.94% as an example here, benefits from a good gene combination. When paired with a partner who has also achieved a low inbreeding coefficient, say 15.02%, the offspring will not necessarily have good genetic values.
If both partners are genetically very similar, despite their own good values, they are not a top combination and the offspring will not be genetically diverse!
So for each combination in advance, use the Mate Select Tool